Effect of a halogen bond on the crystal structure of terphenyldicarboxylic acid derivatives.

The syntheses and structures of dimethyl [1,2:2,3-terphenyl]-1,3-dicarboxylate (1), dimethyl 2,2-diiodo[1,2:2,3-terphenyl]-1,3-dicarboxylate (2), potassium [1,2:2,3-terphenyl]-1,3-dicarboxylate (3) and dimethyl [1,1'-biphenyl]-4,4'-dicarboxylate (4) are reported. Neighboring phenyl rings in compounds 1, 3 and 4 have a planar structure (torsion angles are 0.6-4.

Enhancement of intermolecular aggregation on solvent-influenced strong hydrogen-bonded single crystal.

The intermolecular aggregation between the solvent and organic molecules is covered in the current article. 4,4'-(Buta-1,3-diyne-1,4-diyl)dibenzoic acid (DADBA) was used as an organic molecule and dimethyl sulfoxide (DMSO) as a solvent to create the target compound DADBA-DMSO. The material's hydrogen bonding and intermolecular aggregation were determined by appropriate characterization methods, including single-crystal X-ray diffraction (XRD), Fourier-transform infrared (FTIR), photoluminescence (PL), and cyclic voltammetry (CV) analysis.

1D and 2D coordination polymers with a new rigid chelating linker: diacetylenedisalicylic acid.

Diacetylenedisalicylic acid is a new rigid linker molecule, capable of forming strong chelate bonds with metal cations. Its monosubstituted salts with dimethylamine and sodium form 1D and 2D coordination polymers, whose structures were solved from single crystals, along with the dimethyl ester of diacetylenedisalicylic acid. The structure of the dimethyl ester is characterized by a dense co-facial π-stacking of molecules with a dominance of van der Waals interactions between the stacks.

Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial.

Importance: The large overlap between symptoms of acute sinusitis and viral upper respiratory tract infection suggests that certain subgroups of children being diagnosed with acute sinusitis, and subsequently treated with antibiotics, derive little benefit from antibiotic use.

Objective: To assess if antibiotic therapy could be appropriately withheld in prespecified subgroups.

Design, Setting, And Participants: Randomized clinical trial including 515 children aged 2 to 11 years diagnosed with acute sinusitis based on clinical criteria.