Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging.

Background: Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cognitive decline during aging. The present study examined the role of immune cell activation and inflammation in the link between circadian rhythm dysregulation and cognitive impairment in aging.

Methods: C57Bl/6J mice were exposed to shifted light-dark (LD) cycles (12 h advance/5d) during early adulthood (from ≈ 4-6mo) or continuously to a "fixed" LD12:12 schedule.

Umbilical vein remodeling is associated with pregestational maternal overweight.

Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.

Rheumatic Diseases Following Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis.

Metabolic and bariatric surgery (MBS) has been associated with weight reduction and obesity complications improvement. However, there is no clear evidence of the extent and consistency of the effects of this procedure on rheumatic diseases. This study aims to conduct a meta-analysis to address the impact of MBS on rheumatic diseases.

Nutrition Paradox: Severe Acute Malnutrition Amidst the Proliferation of Processed Foods in Bilaspur's Tribal Region in Chhattisgarh, India.

Despite India's overall economic growth and targeted antimalnutrition efforts, certain districts in Chhattisgarh, exhibit high severe acute malnutrition (SAM) rates, at 17.4% in 2022 per NFHS-5 data. We retrospectively studied four SAM-affected children, finding common factors: maternal malnutrition, poverty, recurrent infections, poor child-rearing knowledge, inadequate birth spacing, and the use and dependence on processed foods.

Electrochemical methods for the determination of acetaminophen in biological matrices: A critical review in the clinical field.

Background: Paracetamol or acetaminophen (APAP), or acetaminophen, is a widely used medication for pain relief and fever reduction due to its analgesic and antipyretic properties. However, excessive APAP consumption can lead to severe hepatotoxicity and nephrotoxicity, posing overdose risks. Consequently, the development of analytical methods for an accurate and rapid detection of APAP in biological matrices is of great interest in the health-related fields.