Lunate prosthetic arthroplasty for the treatment of Kienbock's disease: A systematic review.

Purpose: Prosthetic replacement of the fragmented, collapsed and unreconstructable lunate is a treatment option in Kienbock's disease. The objective of this study is to assess the effectiveness, safety and outcomes of prosthetic lunate arthroplasty for the treatment of Kienbock's disease.

Methods: We conducted a PRISMA-P compliant systematic review PROSPERO (CRD 42021283996) searching Cochrane, Medline, PubMed and Embase databases for the outcomes of prosthetic lunate arthroplasty.

Machine-learning based prediction of hydrogen/methane mixture solubility in brine.

With regard to underground hydrogen storage projects, presuming that the hydrogen storage site has served as a repository for methane, the coexistence of a blend of methane and hydrogen is anticipated during the incipient stage of hydrogen storage. Therefore, the solubility of hydrogen/methane mixtures in brine becomes imperative. On the contrary, laboratory tasks of such measurements are hard because of its extreme corrosion ability and flammability, hence modeling methodologies are highly preferred.

Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy.

The combination of pharmacogenomics and nanotechnology science of pharmacogenomics into a highly advanced single entity has given birth to personalized medicine known as nano-enabled pharmacogenomics. This review article covers all aspects starting from pharmacogenomics to gene editing tools, how these have evolved or are likely to be evolved for pharmacogenomic application, and how these can be delivered using nanoparticle delivery systems. In this prior work, we explore the evolution of pharmacogenomics over the years, as well as new achievements in the field of genomic sciences, the challenges in drug creation, and application of the strategy of personalized medicine.

Inulin: a multifaceted ingredient in pharmaceutical sciences.

Inulin, a naturally occurring polysaccharide derived from plants such as chicory root, has emerged as a significant ingredient in pharmaceutical sciences due to its diverse therapeutic and functional properties. This review explores the multifaceted applications of inulin, focusing on its chemical structure, sources, and mechanisms of action. Inulin's role as a prebiotic is highlighted, with particular emphasis on its ability to modulate gut microbiota, enhance gut health, and improve metabolic processes.