Publications by authors named "K R Steward"

Article Synopsis
  • Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder that leads to very high LDL cholesterol levels and increased risk for heart disease, and lomitapide shows potential to lower LDL cholesterol levels.
  • A study analyzed the effects of lomitapide on 38 women and 37 men with HoFH, finding similar LDL reduction rates for both sexes, although women showed a greater reduction at six months.
  • Women experienced more gastrointestinal side effects from the treatment, but overall, lomitapide was similarly effective for both genders in reducing cholesterol without significant differences in cardiovascular event outcomes.
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E-liquids contain combinations of chemicals, with many enhancing the sensory attractiveness of the product. Studies are needed to understand and characterize e-liquid ingredients, particularly flavorings, to inform future research and regulations of these products. We identified common flavor ingredients in a convenience sample of commercial e-liquids using gas chromatography-mass spectrometry.

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Background And Aims: Proprotein convertase subtilisin/kexin 9 monoclonal antibodies (PCSK9 mAbs) reduce low-density lipoprotein (LDL-c) with a favourable safety profile. Available data from PCSK9 antibody trials suggest LDL-c reduction is lower in women compared to men. Data in real-world setting is scarce.

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