Publications by authors named "K R Singleton"
Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037.
View Article and Find Full Text PDFIntratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of recurrent glioblastoma. This study addresses the need for non-invasive approaches to map heterogeneous landscape of histopathological alterations throughout the entire lesion for each patient. We developed BioNet, a biologically-informed neural network, to predict regional distributions of two primary tissue-specific gene modules: proliferating tumor (Pro) and reactive/inflammatory cells (Inf).
View Article and Find Full Text PDFArticle Synopsis
- Rare inherited diseases caused by mutations in copper transporters (CTR1) lead to copper deficiency, which can cause severe neurological issues like seizures and neurodegeneration in infants.
- The study explores how neuronal cells react to copper deficiency using various genetic model systems, showing that the absence of CTR1 leads to disrupted cellular functions and a shift toward glycolysis.
- Key findings reveal that the activation of the mTORC1-S6K signaling pathway serves as a protective mechanism to enhance protein synthesis in response to copper deficiency, helping to mitigate some of the detrimental effects on neurons.
Article Synopsis
- - Hypermobile Ehlers-Danlos syndrome (hEDS) is a common inherited connective tissue disorder, but its genetic causes are still unknown.
- - Researchers conducted whole exome sequencing on families and sporadic patients with hEDS, discovering a specific missense variant in the KLK15 gene linked to the disease.
- - By creating knock-in mice with this variant, they validated that it caused connective tissue defects, supporting the role of KLK15 gene variants in hEDS and promoting early diagnosis and improved clinical treatments.