Ultimate water capillary evaporation in bamboo-inspired evaporator.

Bionic evaporators inspired by natural plants like bamboo and mushrooms have emerged as efficient generators through water capillary evaporation. However, primitive natural evaporators cannot currently meet growing demand, and their performance limitations remain largely unexplored, presenting a substantial challenge. Through extensive experimentation and detailed simulation analysis, this study presents a precisely engineered H-type bamboo steam generator.

The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning.

Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy response. This study aims to elucidate the role of mitophagy-related genes (MRGs) in cutaneous melanoma (CM) through single-cell RNA sequencing (scRNA-seq) and machine learning approaches, ultimately developing a predictive model for patient prognosis. The scRNA-seq data, bulk transcriptomic data, and clinical data of CM were obtained from publicly available databases.

Seaweed residue hydrolysate enhances the intestinal health, immunity and disease resistance in northern snakehead (Channa argus).

Seaweed residue hydrolysate (SRH), produced by the acid hydrolysis of seaweed processing residues, is rich in bioactive compounds. The development and utilization of SRH as an aquatic immune enhancer not only achieves high-value utilization of waste but also promotes green and healthy aquaculture. In this study, northern snakehead (Channa argus) juveniles fed a compound feed supplemented with SRH (treatment group) exhibited a significant enhancement in intestinal microbial diversity and the proliferation of beneficial bacteria after eight weeks.

Customized Design of Host-Independent T7 Expression System (HITES) for a Broad Host Range.

Efficient methods and universal DNA elements are eagerly required for the expression of proteins and the production of target chemicals in synthetic biology and metabolic engineering. This paper develops a customized-design approach by utilizing the host-independent T7 expression system (HITES), which facilitates the rational design and rapid construction of T7 expression systems. Firstly, the EL (Upper-limit value of initial enzyme activity) value is discovered to play a pivotal factor in the successful construction of the T7 expression system, different host strains exhibit varying EL values, and this study presents a method to measure the EL values.

Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.

The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified NB cells, Aurora kinase A (Aurora-A) binds to and stabilizes N-Myc, resulting in elevated protein levels. Here, we demonstrate that targeted protein degradation of Aurora-A decreases N-Myc levels.