Publications by authors named "K R Shaffer"
Background: Ivacaftor exhibits anti-staphylococcal properties but does not clear from the lungs of people with cystic fibrosis (pwCF). We assessed whether exposure to therapeutic concentrations of ivacaftor could allow to form small colony variants (SCVs), a phenotype commonly associated with bacterial persistence.
Methods: Humanized G551D-CFTR (hG551D) rats were treated with ivacaftor for 7 days.
Article Synopsis
- - The synthesis of crystallizable unnatural amino acid acridon-2-ylalanine (Acd) is refined for large-scale production, allowing its incorporation into proteins through genetic code expansion (GCE) and preparation for solid-phase peptide synthesis (SPPS).
- - Acd is utilized in designing fluorescent protease sensors by leveraging its ability to quench fluorescence when near tyrosine (Tyr) residues, showcasing its application in biochemistry.
- - The study also explores Acd's role in a lanthanide-binding peptide and its insertion into the protein α-synuclein, revealing its effectiveness in studying ion binding and aggregation properties in proteins.
Article Synopsis
- Millennials, as emerging unpaid caregivers, show unique patterns in using digital health technologies compared to older generations, like Baby Boomers and the Silent Generation.
- A study using data from the Health Information National Trends Survey highlighted that Millennial caregivers are more likely to have internet-enabled devices, utilize wearable tech, and choose telehealth for convenience.
- The findings suggest that understanding these differences is important for creating effective digital support interventions tailored to the needs of Millennial caregivers.
Background: Significant insomnia symptoms can have important impacts on the health and quality of life of caregivers of persons with cognitive decline (PwCD).
Objective: To characterize the prevalence of clinically significant insomnia symptoms using the recommended community cutoff for the Insomnia Severity Index (ISI; ≥10) and identify correlates of the presence of symptoms.
Methods: Eighty PwCD caregivers were recruited from a memory and aging care clinic in an academic medical center and completed all study procedures (M = 66.