Publications by authors named "K R Rodgers"
Background And Objectives: Cerebrovascular reactivity (CVR) represents the ability of cerebral blood vessels to regulate blood flow in response to vasoactive stimuli and is related to cognition in cerebrovascular and neurodegenerative conditions. However, few studies have examined CVR in the medial temporal lobe, known to be affected early in Alzheimer disease and to influence memory function. We aimed to examine whether medial temporal CVR is associated with memory function in older adults with and without mild cognitive impairment (MCI).
View Article and Find Full Text PDFA man in his 60s suffered from refractory, biopsy-proven subacute cutaneous lupus erythematosus that required chronic, moderate dose steroids to manage. His rash was accompanied by arthralgias and negative autoantibody testing. His subacute lupus erythematosus (SCLE) was responsive to tofacitinib, but thrombotic complications limited the use of this medication.
View Article and Find Full Text PDFUnlabelled: "Single Model initial-condition Large Ensembles" (SMILEs) conducted with Earth system models have transformed our ability to quantify internal climate variability and forced climate change at local and regional scales. An important consideration in their experimental design is the choice of initialization procedure as this influences the duration of initial-condition memory, with implications for interpreting the temporal evolution of both the ensemble-mean and ensemble-spread. Here we leverage the strategic design of the 100-member Community Earth System Model version 2 (CESM2) SMILE to investigate the dependence of ensemble spread on the method of initialization (micro- vs.
View Article and Find Full Text PDFArticle Synopsis
- HIV-1 infection remains a major global health issue, with around 30 million individuals receiving antiretroviral treatment, where integrase strand-transfer inhibitors (INSTIs) play a key role in effective therapy.
- The research focuses on evaluating the off-target effects of clinically approved INSTIs on recombinase activating genes (RAG1 and RAG2), crucial for the immune system, using various biochemical and cellular tests.
- Results indicate that approved INSTIs have minimal to no adverse effects on RAG activity and V(D)J recombination, supporting their continued use in HIV-1 treatment without significant immune system concerns.
Introduction: Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.
Methods: One hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited.