Publications by authors named "K R Percival"
Objective: This study presents a comparative analysis of RF and SVM for predicting calcein release from ultrasound-triggered, targeted liposomes under varied low-frequency ultrasound (LFUS) power densities (6.2, 9, and 10 mW/cm).
Methods: Liposomes loaded with calcein and targeted with seven different moieties (cRGD, estrone, folate, Herceptin, hyaluronic acid, lactobionic acid, and transferrin) were synthesized using the thin-film hydration method.
Adaptation and validation of an antibiotic prescribing, peer comparison metric for respiratory tract diagnoses in walk-in clinics: a mixed-methods analysis.
Antimicrob Steward Healthc Epidemiol
October 2024
Article Synopsis
- - The study examines antibiotic overuse in walk-in clinics, focusing on the effectiveness of a specific metric that tracks antibiotic prescribing for respiratory tract diagnoses (RTDs) while excluding complicating factors.
- - Data from 331,496 clinic visits between 2018-2022 revealed that 36.5% met RTD criteria, with 36.7% of those receiving antibiotics; factors like patient age and comorbidities influenced prescribing rates.
- - Provider interviews indicated that the RTD metric is acceptable for assessing antibiotic prescribing practices, suggesting it has validity, but further research is needed to evaluate its effectiveness as a feedback tool.
The concept of Digital Twins (DTs), software models that mimic the behavior and interactions of physical or conceptual objects within their environments, has gained traction in recent years, particularly in medicine and healthcare research. DTs technology emerges as a pivotal tool in disease modeling, integrating diverse data sources to computationally model dynamic biological systems. This narrative review explores potential DT applications in medicine, from defining DTs and their history to constructing DTs, modeling biologically relevant systems, as well as discussing the benefits, risks, and challenges in their application.
View Article and Find Full Text PDFIn exploring the challenges of bone repair and regeneration, this review evaluates the potential of bone tissue engineering (BTE) as a viable alternative to traditional methods, such as autografts and allografts. Key developments in biomaterials and scaffold fabrication techniques, such as additive manufacturing and cell and bioactive molecule-laden scaffolds, are discussed, along with the integration of bio-responsive scaffolds, which can respond to physical and chemical stimuli. These advancements collectively aim to mimic the natural microenvironment of bone, thereby enhancing osteogenesis and facilitating the formation of new tissue.
View Article and Find Full Text PDFBackground: To address knowledge gaps in management of Gram-negative bloodstream infection, the Antibiotic Stewardship Implementation Collaborative was established consisting of programs from 24 academic and community hospitals across the United States.
Methods: A retrospective cohort study was conducted of unique adult patients with Gram-negative bloodstream infection hospitalized at participating hospitals from January to December 2019. Patient level and microbiologic data were collected via electronic medical record review with a standardized data collection form and data dictionary.