Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations.

Gut bacteria from the Enterobacteriaceae family are a major cause of opportunistic infections worldwide. Given their prevalence among healthy human gut microbiomes, interspecies interactions may play a role in modulating infection resistance. Here we uncover global ecological patterns linked to Enterobacteriaceae colonization and abundance by leveraging a large-scale dataset of 12,238 public human gut metagenomes spanning 45 countries.

2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids.

Unlabelled: Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the potential to be developed as antivirals.

Predictive Factors of Dental Implant Failure: A Retrospective Study Using Decision Tree Regression.

Introduction: Dental implants are routinely used to replace missing teeth. Therefore, the primary aim of the present study was to assess the single-unit implant failure rate over a period of seven years from 2015 to 2021, with a minimum of two years post-implant follow-up. The secondary aim was to identify the risk factors associated with implant failure using machine learning decision tree regression and Kaplan-Meier survival analyses.

Mortality in Haemophilia Patients in India: A National Cohort Study.

Introduction: Mortality and morbidity in persons with haemophilia (PWH) have decreased due to improved diagnosis and treatment along with comprehensive population outreach efforts, but the impact is not uniform in different countries.

Aim: The study aims to assess all-cause and intracranial haemorrhage (ICH)-specific mortality of PWH in India.

Methods: This is a retrospective, observational, multi-centric cohort study of 1020 haemophilia patients from three centres in India.

Three-dimensional assessment of mandibular canal in different sagittal and growth patterns for safe placement of temporary skeletal anchorage devices: A prospective study.

Introduction: The primary objective of this study was to assess the 3-dimensional position of the mandibular canal (MC) in different craniofacial patterns to know about the safe placement of temporary skeletal anchorage devices using cone-beam computed tomography (CBCT). The secondary objectives were to assess sex differences and correlate the MC position with various factors.

Methods: This prospective, observational study was conducted on 90 patients, divided into 3 groups based on the sagittal pattern: skeletal Class I, Class II, and Class III.