Publications by authors named "K R Mead"
Immunotherapy-related colitis (irC) frequently emerges as an immune-related adverse event during immune checkpoint inhibitor therapy and is presumably influenced by the gut microbiota. We longitudinally studied microbiomes from 38 ICI-treated cancer patients. We compared 13 ICI-treated subjects who developed irC against 25 ICI-treated subjects who remained irC-free, along with a validation cohort.
View Article and Find Full Text PDFObjectives: Despite showing encouraging outcomes, the precision of deep learning (DL) models using different convolutional neural networks (CNNs) for diagnosis remains under investigation. This systematic review aims to summarise the status of DL MRI models developed for assisting the diagnosis of a variety of knee abnormalities.
Materials And Methods: Five databases were systematically searched, employing predefined terms such as 'Knee AND 3D AND MRI AND DL'.
Article Synopsis
- The systematic review aimed to identify recommended pharmaceutical treatments for lumbosacral radiculopathy and assess the quality of clinical practice guidelines (CPGs) using the AGREE II tool.
- The literature search spanned several reputable databases for guidelines published between 2017 and 2022 that addressed issues like radiculopathy and sciatica, specifically focusing on recommendations for oral medications.
- Ultimately, 11 CPGs from seven countries were included in the review, achieving a high mean AGREE II score of 87.1%, indicating strong quality in the guidelines evaluated.
Purpose: The number of cancer survivors in the US surpassed 18.1 million in 2022 and this number continues to grow. Patient self-efficacy, a patient's confidence in his or her ability to self-manage symptoms and healthcare concerns, has been linked to improved health outcomes.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the adverse effects of fluoropyrimidine-based chemotherapy and aims to identify genetic and non-genetic predictors of these side effects.
- Researchers analyzed genomic DNA for 25 single nucleotide polymorphisms (SNPs) and collected demographic and treatment data from 155 Australian participants.
- Results showed associations between multiple genetic and non-genetic predictors with various adverse effects, particularly highlighting diarrhea as the most common severe side effect, and suggest further research is needed to understand these predictors' clinical significance.