Publications by authors named "K R McIntyre"

Background & Aims: The dynamics of HBV viral load (VL) in patients with chronic hepatitis B (CHB) on nucleos(t)ide analogue (NA) treatment and its relationship with liver disease are poorly understood. We aimed to study longitudinal VL patterns and their associations with CHB clinical outcomes.

Methods: Utilising large scale, routinely collected electronic health records from six centres in England, collated by the National Institute for Health and Care Research Health Informatics Collaborative (NIHR HIC), we applied latent class mixed models to investigate VL trajectory patterns in adults receiving NA treatment.

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Background: Surgery is an indispensable component of a functional healthcare system. To date there is limited information regarding how many people die during the perioperative period globally. This study describes a protocol for a systematic review and multilevel meta-regression to evaluate time trends regarding the odds of perioperative mortality among adults undergoing a bellwether surgical procedure while accounting for higher order clustering at the national level.

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Article Synopsis
  • Case reports are crucial for medical learners, helping them engage in scholarship and needing a structured framework for effective writing.
  • An analysis of 1,005 case reports from 2010 to 2019 revealed that 67% were valid case reports, mostly classified as diffusion cases, indicating they educate on known conditions rather than introduce new ones.
  • Authors aiming to publish case reports should be aware that how they frame their work significantly impacts its publishability based on the nature of their contribution to medical literature.
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Article Synopsis
  • Health is influenced by mitochondrial energy transformation, which plays a crucial role in regulating various body systems that relate to resilience and disease risk throughout life.
  • The MiSBIE study aims to explore how mitochondria affect interconnected systems like neuroendocrine, immune, and cognitive functions, focusing on individuals with mitochondrial diseases.
  • This research seeks to enhance understanding of mitochondrial diseases, develop new health biomarkers, and better integrate knowledge of the connections between energy processes and overall health.
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Background And Purpose: It has been suggested that capacity for physical therapy clinical education (CE) experiences is limited; however, data remain unavailable. Regional CE networks have been suggested and may facilitate data collection and management of capacity issues. The Ohio Kentucky Consortium of Physical Therapy Programs developed a Consortium Core Network (CCN) from shared partnerships and implemented a centralized placement process.

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