Publications by authors named "K R McCrae"
Article Synopsis
- - Immune thrombotic thrombocytopenic purpura (iTTP) is a serious condition involving low platelet counts due to a deficiency in the enzyme ADAMTS13, often treated with rituximab to prevent relapses.
- - A study using data from the USTMA registry found that the time without relapse (relapse-free survival or RFS) decreased after each rituximab treatment, particularly for Black patients, suggesting that the effectiveness of the drug diminishes with repeated use.
- - Both the USTMA registry and a separate cohort from Johns Hopkins and the University of Minnesota indicated that Black patients experience a significantly higher risk of relapse with subsequent rituximab treatments, implying a need
Article Synopsis
- Complement-mediated thrombotic microangiopathy (CM-TMA) is a rare disease that affects the blood and kidneys, caused by problems with certain proteins called complement proteins.
- Scientists have created special "biosensors" using cells that glow to help diagnose CM-TMA by checking how these complement proteins work.
- The research suggests that in some patients, a type of immune response involving another protein called IgM may be causing or worsening the disease, even when patients seem to be feeling better.
Article Synopsis
- Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder that leads to severe nosebleeds and related health issues, primarily affecting patients' quality of life due to iron-deficiency anemia from frequent epistaxis.
- A study was conducted where 144 participants were given either pomalidomide or a placebo for 24 weeks to assess the drug's effectiveness in reducing nosebleed severity and improving quality of life, with results favoring the pomalidomide group.
- The results showed that those taking pomalidomide experienced a greater decrease in bleeding scores and improved quality-of-life measures, although there were some additional side effects observed in the pomalidomide group.
Our case depicts a challenging diagnosis of catastrophic antiphospholipid syndrome in a young patient with a heterogenous presentation with extensive clinical course, a wide range of investigations, including multimodality imaging, and multidisciplinary expertise, to initiate prompt treatment addressing multiorgan thrombotic injury.
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