Publications by authors named "K R Marsden"
Continuous professional development (CPD) is crucial for physicians to maintain and enhance their skills. In response to the changing context of CPD and health care, this study applied a design thinking approach to transform and modernise the Royal College of Physicians and Surgeons of Canada's Maintenance of Certification (MOC) Program. A member-wide survey and co-design sessions with physicians, CPD leaders, and patient representatives were conducted, emphasising the importance of their insights and experiences.
View Article and Find Full Text PDFAgricultural soils are a major source of the potent greenhouse gas and ozone depleting substance, NO. To implement management practices that minimize microbial NO production and maximize its consumption (i.e.
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- The larval zebrafish model is valuable across various research fields, especially in studying neuropsychiatric, developmental, and toxicological behaviors through behavioral analysis.
- A study investigated how different testing arena sizes and embryo media affect key behaviors like acoustic startle sensitivity and locomotion in zebrafish larvae, finding that larger arenas reduce startle sensitivity and increase movement.
- Specific components in embryo media also significantly influenced behaviors, and rearing mutant zebrafish for CHARGE syndrome in various media showed changes in observed phenotypes, highlighting the need for standardized approaches in zebrafish behavioral studies.
Animals process a constant stream of sensory input, and to survive they must detect and respond to dangerous stimuli while ignoring innocuous or irrelevant ones. Behavioral responses are elicited when certain properties of a stimulus such as its intensity or size reach a critical value, and such behavioral thresholds can be a simple and effective mechanism to filter sensory information. For example, the acoustic startle response is a conserved and stereotyped defensive behavior induced by sudden loud sounds, but dysregulation of the threshold to initiate this behavior can result in startle hypersensitivity that is associated with sensory processing disorders including schizophrenia and autism.
View Article and Find Full Text PDFArticle Synopsis
- The larval zebrafish is a versatile model for research in various fields, but there is a need for standardized behavioral analysis due to how experimental factors can influence results.
- Testing different arena sizes and types of embryo media revealed that larger arenas lead to reduced startle sensitivity and increased overall movement, while specific media components negatively affected various behavioral responses.
- Understanding these influences allows researchers to choose optimal conditions for their experiments, improving the reliability of findings, especially in genetic and chemical screening studies.