A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane.

A 6-year-old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with a large mucoid component caudal to the primary mass. The mass was removed via transfrontal craniotomy and histopathology revealed a tyrosine crystalline-rich, fibrous meningioma with a high mitotic index.

Cell size is a determinant of stem cell potential during aging.

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function.

Live attenuated Edwardsiella ictaluri vaccines enhance the protective innate immune responses of channel catfish B cells.

Edwardsiella ictaluri causes enteric septicemia of catfish. Our group developed two E. ictaluri live attenuated vaccines (LAVs).

Effects of Live Attenuated Vaccine and Wild Type Strains of on Phagocytosis, Bacterial Killing, and Survival of Catfish B Cells.

, a Gram-negative facultative intracellular pathogen, is the causative agent of enteric septicemia of catfish (ESC). The innate functions of B cells have been demonstrated in several teleost fish, including zebrafish, rainbow trout, and channel catfish. Recently, our group has developed several protective live attenuated vaccines (LAVs).

Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain.

Background/purpose: NGX-4010 (QUTENZA(™); NeurogesX Inc, San Mateo, CA), a capsaicin 8% dermal patch, is licensed in the European Union for the treatment of peripheral neuropathic pain (PNP) in nondiabetic adults and in the United States for the treatment of neuropathic pain associated with postherpetic neuralgia (PHN). While NGX-4010 treatment is associated with a low risk of systemic adverse events, patch application-related pain is common and may be managed with local cooling and/or oral analgesics. This article characterizes the tolerability of NGX-4010 and will help to guide any pain management.