Publications by authors named "K R Mahadik"
Article Synopsis
- Alzheimer's disease is a neurodegenerative disorder marked by neurofibrillary tangles and amyloid plaques, and this research aimed to create a polyherbal gel for its treatment.
- The study involved administering the gel to rats with TMT-induced neurodegeneration, assessing its effects on various brain activity markers and behavioral responses over a 21-day treatment period.
- Results showed better absorption of the gel through the nasal mucosa and significant cognitive improvements in treated rats, alongside increased levels of important neurotransmitters.
The keystone design perforator island flap (KDPIF) is unique among local flaps because of its high potential for adaptation. We describe our experience with the use of the keystone flap for the reconstruction of a variety of defects in different regions of the body concerning its versatility, surgical outcomes, complications, postoperative pain, operative time, and esthetic outcomes. A prospective observational study was conducted at our institute from June 2021 to June 2023 where the use of KDPIFs in resurfacing soft tissue defects of different etiopathogenesis was evaluated and the data were analyzed.
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- XIST long noncoding RNA plays a key role in X chromosome inactivation in placental mammals but is present on both X chromosomes in early human embryos without silencing them.
- XACT lncRNA accumulates alongside XIST on active X chromosomes and may counteract XIST's functions.
- Research using human embryonic stem cells reveals that XIST modifies chromatin and reduces transcription of X-linked genes, while XACT's absence does not significantly impact XIST’s activity or gene expression, indicating that XIST has a role prior to XCI and highlights a mechanism of temporary X chromosome dosage compensation.
The advent of novel 2D and 3D models for human development, including trophoblast stem cells and blastoids, has expanded opportunities for investigating early developmental events, gradually illuminating the enigmatic realm of human development. While these innovations have ushered in new prospects, it has become essential to establish well-defined benchmarks for the cell sources of these models. We aimed to propose a comprehensive characterization of pluripotent and trophoblastic stem cell models by employing a combination of transcriptomic, proteomic, epigenetic, and metabolic approaches.
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