Publications by authors named "K R Khanal"

BRASH syndrome characterized by bradycardia, renal dysfunction, atrioventricular nodal blockade (AVNB), shock, and hyperkalemia presents diagnostic and management challenges due to its complex pathophysiology and varied clinical presentations. We describe a 90-year-old woman with a history of multiple comorbidities who was on beta blockers bisoprolol for heart failure, presented with shock, refractory hyperkalemia along with bradycardia that required intermittent hemodialysis. Initial management involved aggressive hyperkalemia medical therapy and fluid resuscitation, with subsequent consideration of renal replacement therapy hemodialysis following collaboration with a multidisciplinary team, including cardiology and nephrology specialists.

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Introduction: Melanoma, a malignant tumor derived from neural crest melanocytes, predominantly affects the skin but can involve any organ with neural crest migration. Metastatic melanoma of unknown origin, particularly when it involves the brain, is associated with significant morbidity, mortality, and a typically poor prognosis.

Case Presentation: The authors present a 71-year-old man with a history of hypertension and seizure disorder who experienced a headache, transient loss of consciousness, and vomiting.

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This observational study analyzed data from 502 participants undergoing cesarean section (CS) procedures at an obstetrics and gynecology department, aiming to explore anesthesia practices, neonatal outcomes, and demographic characteristics within the cohort. Participants, aged 17 to 59 years with a mean age of 32.23 years, were enrolled based on the clinical necessity for cesarean delivery during the study period.

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Background Lip patterns are normal lines and fissures in the form of wrinkles and grooves present in the zone of transition of the human lip between the inner labial mucosa and the outer skin. Lip patterns are said to be unchangeable and unique. Objective To determine predominant lip patterns found among the Nepali population and to evaluate whether any sex difference exists.

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Article Synopsis
  • Langerhans Cell Histiocytosis (LCH) is a rare pediatric condition caused by an excessive number of abnormal Langerhans cells, typically affecting children aged 1 to 3 and can involve various organs, notably the skeleton and skin.
  • A case study details a 13-month-old boy presenting with fever, rash, and swelling, diagnosed through imaging and a biopsy, resulting in treatment with vinblastine and prednisolone that improved his condition.
  • LCH can manifest in different ways and requires careful diagnosis and treatment based on how widespread the disease is, emphasizing the importance of considering it in cases of ongoing skin and bone issues in children for effective management.*
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