Effectiveness of a Fast- vs. Slow-Velocity Training on Load-Velocity Characteristics in Older Adults: A Pilot Study.

Resistance training at fast velocities is suggested to be more effective for improving muscular strength and movement speed compared to slow, heavy training. This study aimed to examine the effects of a fast-velocity (FVRT) compared to a slow-velocity (SVRT) resistance training program on maximal strength, maximal movement speed, and load-velocity characteristics in older adults. Nineteen community-dwelling older adults were randomly assigned to either the FVRT or SVRT group and completed a twice weekly, progressive resistance training protocol for 8-weeks.

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.

Editing the +58 region of the BCL11A erythroid enhancer has shown promise in treating β-globin disorders. To address variations in fetal hemoglobin (HbF) response, we investigated editing both +58 and +55 enhancers. Rhesus macaques transplanted with edited hematopoietic stem/progenitor cells (HSPCs) following busulfan conditioning exhibited durable, high-level (∼90%) editing frequencies post transplantation with sustained HbF reactivation over 4 years, without hematological perturbations.

Next-generation rapid phenotypic antimicrobial susceptibility testing.

Slow progress towards implementation of conventional clinical bacteriology in low resource settings and strong interest in greater speed for antimicrobial susceptibility testing (AST) more generally has focused attention on next-generation rapid AST technologies. In this Review, we systematically synthesize publications and submissions to regulatory agencies describing technologies that provide phenotypic AST faster than conventional methods. We characterize over ninety technologies in terms of underlying technical innovations, technology readiness level, extent of clinical validation, and time-to-results.

Documenting human papillomavirus vaccine refusal among adolescents in electronic health records: A mixed methods study.

Background: Human papillomavirus (HPV) vaccination is often refused by patients or caregivers. We conducted a mixed-methods study to understand how health care providers document HPV vaccination refusal and use this information in subsequent encounters.

Methods: Using electronic health records (EHR) in a public academic health system, we identified patients aged 9-17 years with documentation of refusal of a recommended vaccination in billing codes or clinic notes from October 15, 2015 and December 31, 2021.

A Nonlinear Peptide Topology for Synthetic Virions.

a nonlinear peptide topology for the assembly of synthetic virions is reported. The topology is a backbone cyclized amino-acid sequence in which polar l- and hydrophobic d-amino acid residues of the same-type alternate. This arrangement introduces pseudo symmetries of side chains within the same cyclopeptide ring, allowing for the lateral propagation of cyclopeptides into networks with a [3/6, 4]-fold rotational symmetry closing into virus-like shells.