Publications by authors named "K R Genschmer"
Article Synopsis
- Cystic fibrosis (CF) modulators have improved patient outcomes, but individual responses vary, especially regarding respiratory issues; the study explores the effects of ketone monoester (KME) on CF patients by boosting D-beta hydroxybutyrate concentrations and assessing quality of life and inflammation.
- Fourteen adults on modulator therapy were divided into two groups: one received KME and the other a placebo for 5-7 days while hospitalized or as outpatients; KME was well tolerated, showing significant increases in D-βHB levels and better self-reported respiratory scores compared to the placebo group.
- Although short-term KME administration didn’t significantly change plasma inflammatory markers, there were notable differences in
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity. Exposure to noxious stimuli such as hyperoxia, volutrauma, and infection in infancy can have long-reaching impacts on lung health and predispose towards the development of conditions such as chronic obstructive pulmonary disease (COPD) in adulthood. BPD and COPD are both marked by lung tissue degradation, neutrophil influx, and decreased lung function.
View Article and Find Full Text PDFMounting evidence demonstrates a role for extracellular vesicles (EVs) in driving lung disorders, such as chronic obstructive pulmonary disease (COPD). Although cigarette smoke (CS) is the primary risk factor for COPD, a link between CS and the EVs that could lead to COPD is unknown. To ascertain whether exposure to CS elicits a proteolytic EV signature capable of driving disease pathogenesis.
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