RNA viruses, TLRs, and cytokines: the perfect storm?

Background: The interactions between virus and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation and healing, which is crucial to resolving infection without destructive immunopathologies.

Summary: Early innate immune responses are key to the generation of a beneficial or detrimental immune response.

A preliminary randomized trial of a brief dissonance-based type 2 diabetes prevention programme for adults with pre-diabetes.

Objective: Conduct a preliminary randomized trial that compared a 6-week type 2 diabetes (T2D) prevention programme to an educational video control for adults with pre-diabetes.

Methods: Adults (N = 62) with pre-diabetes were randomized to the group-delivered Project Health T2D or an educational video control, completing measures at pre-test, post-test and 3-month follow-up.

Results: Participants randomized to the intervention versus control condition showed significantly greater reductions in body fat (d = 0.

Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy.

Viruses have evolved to strategically exploit cellular signaling pathways to evade host immune defenses. GM-CSF signaling plays a pivotal role in regulating inflammation, activating myeloid cells, and enhancing the immune response to infections. Due to its central role in the immune system, viruses may target this pathway to further establish infection.

Image-Based Measures of Obesity are Associated with Alterations in Metabolic Pathways in Non-small Cell Lung Cancer.

Background: Studies suggest that the obesity paradox in non-small cell lung cancer (NSCLC) results from the use of body mass index (BMI) as a measure of obesity. However, the mechanistic basis linking body fat and lung cancer behavior remains unclear. We examined the association of image-based measures of obesity with tumor gene expression to identify transcriptional signatures concordant with adiposity and their underlying biology.

Starship super heavy acoustics: Far-field noise measurements during launch and the first-ever booster catch.

Far-field (9.7-35.5 km) noise measurements were made during the fifth flight test of SpaceX's Starship Super Heavy, which included the first-ever booster catch.