Publications by authors named "K R Fontaine"
Article Synopsis
- The study investigated how insulin sensitivity, insulin response to glucose, and diet affect fat loss and energy expenditure in African American women with obesity.
- 69 women were assigned to either a low-fat or low-carbohydrate diet for 10 weeks, with measures of body composition and energy expenditure taken before and after.
- Results showed that those on a low-CHO diet lost more fat and experienced less decline in energy expenditure than those on a low-fat diet, suggesting low-CHO diets may be more effective for fat loss in this group.
Article Synopsis
- Cystic fibrosis (CF) modulators have improved patient outcomes, but individual responses vary, especially regarding respiratory issues; the study explores the effects of ketone monoester (KME) on CF patients by boosting D-beta hydroxybutyrate concentrations and assessing quality of life and inflammation.
- Fourteen adults on modulator therapy were divided into two groups: one received KME and the other a placebo for 5-7 days while hospitalized or as outpatients; KME was well tolerated, showing significant increases in D-βHB levels and better self-reported respiratory scores compared to the placebo group.
- Although short-term KME administration didn’t significantly change plasma inflammatory markers, there were notable differences in
Mitochondrial dysfunction and associated inflammatory signaling are pivotal in both aging and in Alzheimer's disease (AD). Studies have also shown that hypothalamic function is affected in AD. The hypothalamus may be a target for AD drugs given that mitochondrial alterations are observed in the hypothalamus.
View Article and Find Full Text PDFThe tutelage of our mentors as scientists included the analogy that writing a good scientific paper was an exercise in storytelling that omitted unessential details that did not move the story forward or that detracted from the overall message. However, the advice to not get lost in the details had an important flaw. In science, it is the many details of the data themselves and the methods used to generate and analyze them that give conclusions their probative meaning.
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- Scrub typhus is a serious disease transmitted by mites, with the presence of eschar being a key indicator, yet its frequency varies among Indian patients.* -
- A comprehensive review analyzed 107 studies involving over 34,000 scrub typhus cases, finding an overall eschar positivity rate of 28.5%, with significant geographic differences—higher rates in Tamil Nadu and Tripura compared to other regions like Haryana and Rajasthan.* -
- The majority of eschars were located on the trunk, groin, and axilla, emphasizing the need for physicians to conduct thorough physical exams for better diagnosis and awareness.*