Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors.

Background: Anti-human epidermal growth factor receptor 2 (HER2) IgG1-based antibody therapies significantly improve cancer prognosis, yet intrinsic or acquired resistance to fragment antigen-binding (Fab)-mediated direct effects commonly occurs. Most resistant tumors retain antigen expression and therefore remain potentially targetable with anti-HER2 therapies that promote immune-mediated responses. Tumor-antigen-specific IgE class antibodies can mediate powerful immune cell-mediated effects against different cancers and have been shown to activate IgE Fc receptor-expressing monocytes.

Baseline physical and cognitive functions associate with the longitudinal trajectory of stigma in patients with multiple sclerosis (MS).

Background: Multiple sclerosis is a chronic disease, and the lived experience of a person with MS is highly heterogeneous.

Objective: To analyze longitudinal trajectories of stigma in MS, the associated baseline predictors, and how the stigma trajectories relate to the longitudinal changes in physical disability.

Method: In a cohort of people from the MS Partners Advancing Technology and Health Solutions (MS PATHS) network with at least two stigma measures, we analyzed the trajectory of stigma and physical disability by applying a group-based trajectory modeling (GBTM) to longitudinal measures of Neuro-QoL stigma T-score and Patient Determined Disease Steps (PDDS), respectively.

Engaging Health and Aged Care Workers in Rural and Remote Australia Around Factors Impacting Their Access to and Participation in Dementia Training.

To better understand barriers and enablers to uptake of dementia training in rural and remote areas using input from rural and remote aged and health care workers into how dementia training could be offered to better meet their needs. : Roundtable focus groups were conducted in six diverse rural and remote locations in four jurisdictions around Australia. Sixty-seven workers from predominantly nursing, allied health, and support worker roles involved in dementia care participated.

Assessing the uptake of the core outcome set in randomized controlled trials for coronary artery disease: a trial registry analysis.

Background: Coronary artery disease (CAD) is a global health crisis, responsible for nearly 20 million deaths annually worldwide and 12.6% of all deaths in the United States. Randomized controlled trials (RCTs) are critical for developing evidence-based clinical guidelines, but inconsistent outcome reporting across RCTs hinders evidence synthesis and comparability.