Publications by authors named "K R Cradock"
Extracellular vesicles (EVs) have been implicated in metastasis and proposed as cancer biomarkers. However, heterogeneity and small size makes assessments of EVs challenging. Often, EVs are isolated from biofluids, losing spatial and temporal context and thus lacking the ability to access EVs in situ in their native microenvironment.
View Article and Find Full Text PDFNumerous factors influence insect colonization and development on decomposing remains and can influence postmortem interval (PMI) estimations when insects are used in investigations of suspicious deaths. This study aimed to determine whether insect repellent influences insect colonization of decomposing remains. Pig feet were divided into 4 groups: a control not sprayed with repellent, 40% DEET repellent, 98% DEET repellent, and lemon eucalyptus repellent.
View Article and Find Full Text PDFBackground: Individual responses to behavioural weight loss interventions can vary significantly, and a better understanding of the factors associated with successful treatment might help to target interventions for those who will benefit the most. We sought to identify demographic and clinical characteristics that predicted intervention "success" (defined as ≥5% weight loss) and other health gains in patients with severe obesity attending a ten-week structured lifestyle modification programme.
Methods: We conducted a prospective cohort study of all 1122 patients (751 (66.
Article Synopsis
- Recent advancements in optical bioimaging have generated detailed structural and functional data from biological samples, which require advanced computational tools for pattern recognition and relationship analysis in biomedical contexts.
- A weakly supervised deep learning framework is introduced, which utilizes a multiple instance learning classifier and model interpretation techniques to identify regions of interest in images with coarsely labeled data, aiding in optical signature discovery.
- Applied to breast cancer research, this framework achieved a high accuracy in cancer diagnosis and uncovered novel optical signatures in normal-appearing breast tissue, offering new insights into cancer biology and the potential for application in various imaging tasks.
Background: Surgical quality improvement collaboratives (QICs) aim to improve patient outcomes through coaching, benchmarked data reporting, and other activities. Although other regional QICs have formed organically over time, it is unknown whether a comprehensive quality improvement program implemented simultaneously across hospitals at the formation of a QIC would improve patient outcomes.
Study Design: Patients undergoing surgery at 48 hospitals in the Illinois Surgical Quality Improvement Collaborative (ISQIC) were included.