Publications by authors named "K R Clifford"

Background: Hartmann's procedure (sigmoid resection with end colostomy) is a commonly performed emergency procedure for diseases of the sigmoid colon.

Aim: To determine the proportion of patients undergoing Hartmann's reversal (restoration of GI continuity) following Hartmann's procedure, the clinical and demographic factors associated with reversal, and the reasons for non-reversal.

Method: This is a single center, retrospective audit of patients undergoing Hartmann's procedure between June 2011 and May 2020.

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Introduction: Compression stocking therapy is the gold standard of treatment for conditions associated with lower limb venous dysfunction. The benefits in symptom relief and preventing disease progression are well documented. Despite this, adherence to compression stocking therapy is poor.

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Article Synopsis
  • The Inflation Reduction Act of 2022 mandates Medicare to negotiate drug prices, allowing negotiations for small-molecule drugs nine years after FDA approval and for biologics thirteen years postapproval.
  • A comparison of small-molecule drugs and biologics from 1999-2018 showed similar incremental quality-adjusted life-year (QALY) gains, but significant differences in costs and cost-effectiveness.
  • Small-molecule drugs had lower additional costs and better cost-effectiveness ratios compared to biologics, suggesting a potential need for equalizing negotiation timelines for both types of drugs.
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Solution-processed nanomaterials can be assembled by a range of interfacial techniques, including as stabilizers in Pickering emulsions. Two-dimensional (2D) materials present a promising route toward nanosheet-stabilized emulsions for functional segregated networks, while also facilitating surface energy studies. Here, we demonstrate emulsions stabilized by the 2D materials including the transition metal carbide MXene, titanium carbide (TiCT ), and develop an approach for measurement of nanosheet surface energy based on emulsion inversion.

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Background: Substance use disorders (SUDs) are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, there remain significant gaps in our understanding of EFs in SUDs, including the dimensional relationships of EFs to underlying neural circuits, molecular biomarkers, disorder heterogeneity, and functional ability.

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