Multi-omic insights into molecular mechanism and therapeutic targets in spinocerebellar ataxia type 7.

Recent advances in molecular science have significantly enlightened our mechanistic understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we performed a multi-omics analysis using SCA7 mice. Entire brain tissue samples were collected from 12-week-old mice, and RNA sequencing, methylation analysis, and proteomic analysis were performed.

Associations between serum cytokine levels and postmenopausal depression in postmenopausal women with and without menopause hormone therapy.

Background: The etiology of depression involves many biological and environmental factors, among which the inflammatory process is an important contributor. However, the role of pro-inflammatory cytokines in postmenopausal depression is unclear. Therefore, we aimed to explore the association between the serum concentrations of four pro-inflammatory cytokines (IL-1β, IL-6, IL-18, and TNF-α) and depressive symptoms in postmenopausal women who had been receiving menopause hormone therapy (MHT) for at least 6 months and postmenopausal women who had not received MHT.

Dual-Nano Composite Design with Grain Boundary Segregation for Enhanced Strength and Plasticity in CoCrNi-CuZr Thin Films.

Enhancing both strength and plasticity simultaneously in nanostructured materials remains a significant challenge. While grain refinement is effective in increasing strength, it typically leads to reduced plasticity due to localized strain. In this study, we propose a novel design strategy featuring a dual-nano composite structure with grain boundary segregation to enhance the deformation stability of nanostructured materials.

Main-Group Sn Single Atoms on MoS for Selective Nitrite Electroreduction to Ammonia.

Electrocatalytic NO-to-NH reduction (NORR) offers an attractive way to remedy polluted NO and produce value-added NH. In this study, main-group Sn single atoms anchored on S-vacancy-rich MoS (Sn/MoS) are explored as a highly selective NORR catalyst. Combined theoretical computations and in situ spectroscopic measurements reveal that the isolated Sn sites of Sn/MoS can not only promote NO-to-NH activation and hydrogenation but also favor NH desorption and restrict H adsorption, thus enabling a highly selective NORR for NH synthesis.

Protection induced by recombinant vaccinia virus targeting the ROP4 of Toxoplasma gondii in mice.

Toxoplasmosis is a parasitic disease affecting a significant portion of the global population, whose etiology can be attributed to the protozoan organism Toxoplasma gondii. Despite its public health importance, an efficacious vaccine to prevent human toxoplasmosis remains unavailable. To this end, we designed an experimental toxoplasmosis vaccine using recombinant vaccinia virus vectors (rVacv) expressing the T.