Publications by authors named "K R Blum"
Purpose: Renal medullary carcinoma (RMC) is a highly aggressive malignancy defined by the loss of the SMARCB1 tumor suppressor. It mainly affects young individuals of African descent with sickle cell trait, and it is resistant to conventional therapies used for other renal cell carcinomas. This study aimed to identify potential biomarkers for early detection and disease monitoring of RMC.
View Article and Find Full Text PDFAvailability of toxicological data for pharmaceutical intermediates (IMs) used in the manufacture of small molecules is often limited. Scarcity of data - in particular, repeat-dose toxicity (RDT) - renders the calculation of health-based exposure limits (HBELs) problematic. Establishment of HBELs, including occupational exposure limits (OELs) and permitted daily exposures (PDEs) facilitating worker and patient safety respectively, is however essential.
View Article and Find Full Text PDFArticle Synopsis
- - The paper discusses the importance of intervention and implementation fidelity in healthcare research, emphasizing that strict adherence to core components of interventions is crucial for meaningful evaluation of outcomes.
- - It highlights the need for flexibility in defining fidelity, as varying contexts and implementation strategies require researchers to adapt their approaches while ensuring that fidelity criteria are transparent and context-dependent.
- - The authors argue that fidelity assessments should consider not just individual behaviors, but also organizational and system factors, further complicating the evaluation process and necessitating a deeper understanding of fidelity concepts.