Publications by authors named "K R Balaji"
The present studies were undertaken to understand the effects of the commonly used nutraceutical PEA on brain function and lipid chemistry. These studies using MRI and broad-scale lipidomics are without precedent in animal or human research. During the MRI scanning session awake rats were given one of three doses of PEA (3, 10, or 30 mg/kg) or vehicle and imaged for changes in BOLD signal and functional connectivity.
View Article and Find Full Text PDFInvestigation of radiomic features on MRI images to identify extraprostatic extension in prostate cancer.
Comput Methods Programs Biomed
February 2025
Article Synopsis
- This study focuses on identifying extraprostatic extension (EPE) in prostate cancer patients using advanced imaging techniques, highlighting its importance for treatment outcomes.
- Researchers analyzed MRI scans from 20 patients who underwent surgery, extracting over 200 radiomic features to help differentiate between EPE and non-EPE lesions.
- The results showed that an MLP neural network model using 18 key features could accurately predict EPE, achieving a sensitivity of 75%, specificity of 79%, and an area-under-curve (AUC) of 0.82, indicating promising predictive capability.
Dynamic contrast enhancement (DCE) imaging is a valuable sequence of multiparametric magnetic resonance imaging (mpMRI). A DCE sequence enhances the vasculature and complements T2-weighted (T2W) and Diffusion-weighted imaging (DWI), allowing early detection of prostate cancer. However, DCE assessment has remained primarily qualitative.
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- HPV vaccines were introduced in 2006 to prevent cancers caused by the virus, especially cervical cancer, which is a leading cause of death worldwide.
- There are currently six licensed HPV vaccines, four of which are recognized by the World Health Organization, with more products being developed.
- The article discusses the potential of a single-dose vaccine regimen to increase access and affordability, improve supply, and effectively reduce HPV-related health issues.
Background: The E-cadherin, α- and β-Catenin interaction at the cell adherens junction plays a key role in cell adhesion; alteration in the expression and function of these genes are associated with disease progression in several solid tumors including prostate cancer. The membranous β-Catenin is dynamically linked to the cellular cytoskeleton through interaction with α-Catenin at amino acid positions threonine 120 (T120) to 151 of β-Catenin. Nuclear presence of α-Catenin modulates the sensitivity of cells to DNA damage.
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