Associations between bone material strength index and FRAX scores.

Introduction: Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, its ability to predict fractures is still uncertain. This study aimed to determine the association between BMSi and 10 year fracture probability, as calculated by the FRAX algorithm.

Neonatal inflammation and near-term white matter microstructure in infants born very preterm.

Background: Severe neonatal inflammatory conditions in very preterm infants (VPT: <32 weeks gestational age, GA) are linked to adverse neurodevelopmental outcomes. Differences in white matter (WM) microstructure of the corpus callosum (CC) have been observed at age 6 in VPT children with a history of severe neonatal inflammation. The goal of this study was to determine whether these CC differences can be detected at term-equivalent age using diffusion MRI (dMRI), and whether neonatal inflammation is associated with altered WM in additional tracts implicated in the encephalopathy of prematurity.

Divergent Transport Dynamics of Alkylated versus Unsubstituted Polycyclic Aromatic Hydrocarbons at the Air-Water and Sediment-Water Interfaces at a Legacy Creosote Site.

Alkylated polycyclic aromatic hydrocarbons (PAHs) are abundant constituents of many PAH mixtures and contribute to risk at contaminated sites. Despite their abundance, the movement of alkylated PAHs remains understudied relative to unsubstituted PAHs. In the present study, passive sampling devices were deployed in the air, water, and sediments at 11 locations across multiple seasons to capture spatial and temporal variability in the abundance and movement of alkylated PAHs at a Brownsfield creosote site in Oregon, USA.

Open lower limb fracture reconstruction in the elderly population: the experience of a major trauma centre.

Purpose: Management of the elderly patients presenting with open lower limb fractures is challenging due to physiological changes and pre-existing co-morbidities. The aim of this study was to assess the compliance with the British Orthopaedic Association's Standards for Trauma Number 4 (BOAST 4) guidelines in this patient group.

Methods: The study included a retrospective analysis of all the patients aged > 65 years old admitted with open lower limb fracture between 2017 and 2019 to a major trauma centre (MTC) in East of England.

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma.

Efficacy and durability remain central shortcomings of T-cell based therapies in multiple myeloma (MM). Here, we employ blood-based transcriptional T-cell profiling to define impaired T-cell fitness as putative biomarker associated with sensitivity to PD1 inhibition in CAR-T refractory MM patients.