Publications by authors named "K Purshouse"
Background: Although rare, uterine sarcomas account for a high proportion of uterine cancer mortality. Treatment options and robust trial data are limited.
Objectives: The TOURISM study (Treatment Outcomes in UteRIne SarcoMa) is a UK-wide study by the National Oncology Trainees Collaborative for Healthcare Research which aimed to characterise this patient cohort.
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring and targeting ecDNA vulnerabilities as potential new therapeutic targets for cancer treatment.
View Article and Find Full Text PDFAdult brain tumour research in 2024: Status, challenges and recommendations.
Neuropathol Appl Neurobiol
April 2024
Article Synopsis
- In 2015, patient and charity activism led to the formation of a UK government group focused on brain tumor research.
- By 2018, this resulted in a commitment of £20m from the government and £25m from Cancer Research UK for neuro-oncology over five years.
- The review covers changes in the UK's brain tumor research landscape, identifies seven key research priorities, three overarching themes, and discusses the current status and challenges in this field.
Article Synopsis
- This study examined the safety and tolerability of the anti-PD-1 drug pembrolizumab in patients with non-muscle-invasive bladder cancer (NMIBC) following bladder tumor removal surgery (TURBT).
- Six patients received intravesical pembrolizumab in increasing doses (50 mg to 200 mg) without significant safety issues or dose-limiting toxicities.
- The treatment was well-tolerated with mild side effects and no signs of systemic absorption or immune system changes, suggesting further research is needed to evaluate the potential benefits of this administration method.
Background: Cancer and anti-cancer treatment (ACT) may be risk factors for severe SARS-CoV-2 infection and limited vaccine efficacy. Long-term longitudinal studies are needed to evaluate these risks. The Scottish COVID cancer immunity prevalence (SCCAMP) study characterizes the incidence and outcomes of SARS-CoV-2 infection and vaccination in patients with solid tumors undergoing ACT.
View Article and Find Full Text PDF