Comparative evaluation of the dissociation rate between the vaginotrophic and uterotrphic activities of 1-hydroxy-1, 3, 5 (10)-estratriene derivatives with natural and unnatural configuration at C8 using ovariectomized mice.

Influences on estrogenic.activities of 1-hydroxylation and C8-isomerization in the molecules of naturally occurring estrogens have been studied. All compounds tested behaved qualitatively in the same manner as estradiol, as far as the decrease in the vaginal and uterine sialic acid levels and the increase in the organ weights of the vagina and uterus of castrated mice are concerned.