[Study of principles in pathogenesis and therapy of fat embolism. IV. In vivo studies of drug-induced mobilization of embolized lung fat].

Pluronic F 108 added to serum in a concentration of 1 g/dl proved as the optimal means to increase the fat emulgatory capacity. Similar concentrations were achieved in living rabbits by infusing 4.5 g per kg body weight.

[Basis examinations for pathogenesis and treatment of fat embolism. III. The interface tension of blood against lipids. B. Their influence by addition of surfactants and the effect on the lipid solubility in vitro].

Various surfactants such as Pluronic L 61, L 64, F 68 and F 108, Tween 80 und Triton WR 1339 as well as bile acids and sodium taurocholate were tested for their capacity to reduce the interface tension against neutral lipids and for their capacity to induce stable emulsions of triglycerides in rabbit sera. No positive correlation was found to exist between the interface activity against neutral lipids and the lipid emulsifying capacity of rabbit sera, added with the surfactants. When ether was added to serum, the lipid emulsifying capacity was increased most at concentrations of about 0,0075 g ether per 100 ml serum.

[Investigations concerning the mechanism of contrast damage. The significance lipophilia (author's transl)].

The damaging action on vascular endothelia of meglumin iothalamate and of meglumin ioxitalamate was tested on the rat aorta. Ioxitalamate was significantly better tolerated than iothalamate. The octanol-water-partition coefficient of various contrast media was evaluated by assessing the iodine content of the octanol phase after mixing.