Publications by authors named "K Pondman"
Article Synopsis
- The classical pathway of the complement system is initiated when C1q binds to target activators, including immune complexes, while factor H primarily regulates the alternative pathway but can also influence the classical pathway by competing for binding sites with C1q.
- Both C1q and factor H can recognize and bind to foreign or altered-self materials, including fibrin clots, which can activate the classical complement pathway through mechanisms involving FXIIIa.
- The study showed that fibrin clots do indeed activate the classical pathway, leading to complement activation, but factor H effectively downregulates this activation, highlighting the complex interplay between the complement and coagulation systems.
Nanoparticles (NPs) are not only employed in many biomedical applications in an engineered form, but also occur in our environment, in a more hazardous form. NPs interact with the immune system through various pathways and can lead to a myriad of different scenarios, ranging from their quiet removal from circulation by macrophages without any impact for the body, to systemic inflammatory effects and immuno-toxicity. In the latter case, the function of the immune system is affected by the presence of NPs.
View Article and Find Full Text PDFAccurate determination of the CYP2D6 (*1/*4)xN genotype by quantitative PCR.
Drug Metab Pers Ther
March 2018
Background: CYP2D6 is responsible for the metabolism of approximately 25% of all drugs. The expression of cytochrome P450 2D6 (CYP2D6) is influenced by a combination of factors including polymorphisms in the CYP2D6 gene. Analysis of the CYP2D6 genotype is used to personalize the medication to a patient's metabolism.
View Article and Find Full Text PDFWe report two families, members of which are carriers of a hemoglobin (Hb) variant previously described as Hb Nouakchott [α114(GH2)Pro→Leu; HBA1: c.344C>T; p.Pro115Leu].
View Article and Find Full Text PDFArticle Synopsis
- Nanomaterials, like carbon nanotubes (CNTs), need to be biocompatible and target-specific for therapeutic use, as the immune system tends to recognize them as foreign substances.* -
- Studies show that CNTs interact with immune cells, influencing their internal processing and overall immune response, particularly through interactions with the complement system.* -
- The modification of CNT surfaces affects complement activation, which can enhance or reduce inflammation and improve the effectiveness of these materials in therapeutic applications.*