Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.

High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers presenting in the inherited condition hereditary nonpolyposis colorectal cancer (HNPCC). Distinction between these categories of MSI-H cancer is of clinical importance and the aim of this study was to assess clinical, pathological, and molecular features that might be discriminatory. One hundred and twelve MSI-H colorectal cancers from families fulfilling the Bethesda criteria were compared with 57 sporadic MSI-H colorectal cancers.

Leiomyosarcoma of the broad ligament coincident with ductal carcinoma of the breast.

Presented is a case of an isolated leiomyosarcoma of the broad ligament in a woman who had a synchronous ductal carcinoma of the breast. Carcinoma of the breast, thyroid, or colon is the most common second primary neoplasm in women with pelvic malignancy.