Publications by authors named "K Pichavant-Rafini"

Selenium contributes to physiological functions through its incorporation into selenoproteins. It is involved in oxidative stress defense. A selenium deficiency results in the onset or aggravation of pathologies.

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In intensive care units, sepsis is the first cause of death. In this pathology, inflammation and oxidative status play a crucial role in patient outcomes. Interestingly, 92% of septic patients exhibit low selenium plasma concentrations (a component of antioxidant enzymes).

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Decompression sickness (DCS) is a complex and poorly understood systemic disease with wide interindividual resistance variability. We selectively bred rats with a threefold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechanisms, 15 males and 15 females resistant to DCS were compared with aged-matched standard Wistar males ( = 15) and females ( = 15).

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Article Synopsis
  • The study explores how high hydrostatic pressure (10.1 MPa) affects turbot liver cells exposed to different types of oil and dispersants, highlighting the importance of ecotoxicological research after the DeepWater Horizon oil spill.
  • It was found that oil exposure led to increased cell viability despite no notable changes in overall cell mortality, suggesting that stress responses differ under these conditions.
  • The research also indicates that while oil exposure under pressure raises cellular oxygen consumption, the presence of dispersant prevents this increase, hinting at complex interactions that require further investigation.
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