Publications by authors named "K Pawlish"
Importance: Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer. Quantifying the contribution of major potentially modifiable risk factors to the burden of MCC may inform prevention efforts.
Objective: To estimate the population attributable fraction of MCC cases in the US that were attributable to major immunosuppressing conditions (eg, HIV, solid organ transplant, chronic lymphocytic leukemia [CLL]), ambient UV radiation [UVR] exposure, and Merkel cell polyomavirus [MCPyV]).
Background: Cancer risk among people with HIV (PWH) has declined over time as a result of antiretroviral therapy, but it is unclear whether all racial/ethnic groups and transmission risk groups have experienced equal declines.
Methods: We used data on PWH aged ≥20 years old from the HIV/AIDS Cancer Match Study during 2001-2019. We used Poisson regression to assess time trends in incidence rates for each cancer site by racial/ethnicity and risk group, adjusting for age, registry, and sex.
A previous cancer diagnosis can preclude patients from consideration for solid organ transplantation. Statistical models may improve candidate selection. We fitted statistical cure models and estimated 5-year cancer-specific survival (5yCSS) for colorectal cancer patients in the United States using registry data.
View Article and Find Full Text PDFArticle Synopsis
- Cardiovascular health (CVH) is vital for Black breast cancer survivors, particularly due to potential heart-related side effects from treatments, and neighborhood factors may impact their health outcomes.
- This study analyzed 713 Black breast cancer survivors in New Jersey to examine how their neighborhood characteristics, defined through social and environmental features, relate to their CVH scores 24 months post-diagnosis.
- Results showed that survivors living in certain neighborhoods, particularly the Mostly Culturally Black and Hispanic/Mixed Land Use archetype, had the lowest CVH scores, while those in more diverse neighborhoods had significantly better health outcomes, especially among younger women.
Article Synopsis
- Immunosuppressed individuals, such as those with HIV and solid organ transplant recipients, face a higher risk of developing certain cancers, prompting a study to identify specific cancer types associated with these conditions.* -
- Researchers analyzed cancer registry data in the U.S., finding a total of 38,047 cancer cases among organ transplant recipients and 53,592 among individuals with HIV, with elevated standardized incidence ratios of 1.66 and 1.49 respectively.* -
- Specific cancers, like conjunctival squamous cell carcinoma, showed significantly higher risks in both populations, while others, such as sebaceous adenocarcinoma, were particularly heightened in solid organ transplant recipients, emphasizing the need for awareness and monitoring in these