Publications by authors named "K PHILIPP"
Background: Patients diagnosed with Marfan syndrome or a related syndrome require frequent aorta monitoring using imaging techniques like transthoracic echocardiography (TTE) and computed tomography (CT). Accurate aortic measurement is crucial, as even slight enlargement (>2 mm) often necessitates surgical intervention. The 2022 ACC/AHA guideline for Aortic Disease Diagnosis and Management includes updated imaging recommendations.
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- Researchers are developing a new method for detecting trace gases in the air using ionization energies, which can be miniaturized and fine-tuned.
- Traditional methods for identification rely on large equipment, like mass spectrometers, but this new approach uses electron impact ionization, generated via the photoelectric effect, for better sensitivity at a lower scale.
- The method achieves sensitivity levels of 1 ppm, comparable to classic photoionization detection (PID), and can identify substances with an accuracy of 30 meV, supported by quantum mechanical models.
Is Marfan Syndrome Associated with Primary Structural Changes in the Left Atrium?
Diagnostics (Basel)
October 2023
Marfan syndrome (MFS) is an autosomal-dominant multisystem connective tissue disorder that is based on mutations in the gene and variably affects different organs, including the heart. In this study, we investigated cardiac function with a focus on the left atrium (LA) in a relatively large cohort of patients with MFS. After screening of 1165 patients that had been examined in our center between 2016 and 2020, 231 adult MFS patients with and without aortic operation were included in our study and compared to a healthy control group ( = 106).
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- The study aimed to gather clinical and epidemiological data on patients with orofacial clefts in Lower Saxony, analyzing records from 404 surgical cases at the University Medical Center Goettingen from 2001 to 2019.
- The prevalence of orofacial clefts was found to be 1:890, with cleft lip and palate (CLP) being the most common type, and almost 10% of patients had syndromic conditions; factors like family history and pregnancy complications were also examined.
- The findings highlighted the need for specialized care, as the profiles of syndromic CL/P and associated health issues were significant, aligning with trends seen in other Western populations.
The physician has to make numerous and legally far-reaching determinations in the course of the post-mortem examination. These can have considerable consequences for relatives and, moreover, for society. Therefore, the correct performance of post-mortem examinations and the correct evaluation of the findings is an extremely responsible task that every physician should master.
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