Publications by authors named "K PABST"
Accurate navigation often requires the maintenance of a robust internal estimate of heading relative to external surroundings. We present a model for angular velocity integration in a desert locust heading circuit, applying concepts from early theoretical work on heading circuits in mammals to a novel biological context in insects. In contrast to similar models proposed for the fruit fly, this circuit model uses a single 360° heading direction representation and is updated by neuromodulatory angular velocity inputs.
View Article and Find Full Text PDFObjective: FAPI-PET/CT exhibits high tumor uptake and low background accumulation, enabling high-sensitivity tumor detection. We compared the diagnostic performance of Ga-FAPI-46 PET/CT plus contrast-enhanced CT (CE-CT), F-FDG PET/CT plus CE-CT, and standalone CE-CT in patients with various malignancies.
Methods: 232 patients underwent Ga-FAPI-46 PET/CT,F-FDG PET/CT, and CE-CT each within 4 weeks.
Purpose: In metastatic castration-resistant prostate cancer (mCRPC), some patients show low/absent PSMA expression in tumour lesions on positron emission tomography (PET) scans, indicating heterogeneity and heightened risk of non-response to PSMA-RLT (radioligand therapy). Imaging cancer-associated fibroblasts and glucose uptake may further characterise tumour heterogeneity in mCRPC patients. Here, we aimed to evaluate tumour heterogeneity and its potential implications for management in mCRPC patients assessed for PSMA-RLT using [Ga]Ga-FAPI-46, 2-[F]FDG and [Ga]Ga-/[F]F-PSMA-11/-1007 PET.
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- Scientists are studying a special tool called FAPIs that helps see tumors in the body, especially in autoimmune thyroiditis (AIT), which is a thyroid disease.
- They looked at patients with AIT and noticed that their thyroids were using more FAPIs and glucose in scans compared to healthy people.
- It's important to be careful when interpreting these results because finding thyroid issues in scans could mean patients need more check-ups.
The fibroblast activation protein (FAP) is highly expressed in tumor and stromal cells of mesothelioma and thus is an interesting imaging and therapeutic target. Previous data on PET imaging with radiolabeled FAP inhibitors (FAPIs) suggest high potential for superior tumor detection. Here, we report the data of a large malignant pleural mesothelioma cohort within a Ga-FAPI46 PET observational trial (NCT04571086).
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