Publications by authors named "K P Wenzel"
Extended-release buprenorphine induction in opioid non-tolerant incarcerated individuals.
Drug Alcohol Depend Rep
September 2024
Background: Buprenorphine maintenance treatment remains unavailable in most jails in the US. We provide data on a four-day rapid sublingual buprenorphine (SL-B) induction strategy followed by a weekly dose of extended-release injectable buprenorphine (XR-B) with incarcerated individuals with opioid use disorder (OUD) who were not opioid tolerant.
Methods: Between October 2020 to April 2024, = 65 individuals with an opioid use disorder in jails participating in a larger randomized, controlled trial received SL-B and XR-B prior to release.
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor-neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are not yet fully understood. In this study we investigated whether Sac/Val influences the two proteolytic systems, the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP), in a mouse model of pressure overload induced by transverse aortic constriction (TAC) and in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with endothelin-1 (ET1) serving as a human cellular model of hypertrophy.
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- This study highlights that rates of PTSD are higher among sexual minority adults (LGB+) compared to heterosexual individuals, especially in the context of substance use disorders (SUD).
- The research found that LGB+ individuals reported experiencing more trauma, higher PTSD severity, and greater difficulties with emotion regulation than their heterosexual counterparts.
- Importantly, when emotion regulation difficulties were taken into account, the link between being a sexual minority and experiencing severe PTSD symptoms became less significant, suggesting that improving emotion regulation may help reduce PTSD severity in this population.
Article Synopsis
- This study explores how Adverse Childhood Experiences (ACEs) affect the risk of developing Posttraumatic Stress Disorder (PTSD) in adults undergoing residential treatment for Substance Use Disorder (SUD), suggesting a link between impulsivity and PTSD.
- The research involved 134 adults in treatment, using questionnaires to measure their levels of ACEs, PTSD symptoms, and impulsivity, ultimately finding that two-thirds of participants showed potential PTSD symptoms.
- Among various impulsivity traits examined, lack of premeditation specifically partially mediated the connection between ACEs and PTSD symptoms, highlighting its importance in understanding PTSD development in the context of SUD.
An Assertive Community Intervention to Engage Youth with Opioid Use Disorder and Their Families.
Child Adolesc Psychiatr Clin N Am
October 2024
Medications for opioid use disorder (MOUD) are the most effective treatment for OUD. Many patients struggle with adherence, but young adults face unique developmental barriers and experience higher relapse rates. The Youth Opioid Recovery Support (YORS) intervention is a developmentally informed behavioral approach to increase medication adherence through assertive outreach, family involvement, low-barrier access to extended-release MOUD, and contingency management.
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