Efficacy of Cognitive Interventions in Mild Cognitive Impairment due to Alzheimer's Disease- An Open-Labelled Exploratory Analysis.

Background: Efficacy data on nonpharmacotherapy-based interventions such as cognitive retraining and mindfulness meditation on improving neuropsychological functioning in early Alzheimer's disease (AD) are sparse in Indian literature.

Objective: The objective of the study was to quantify the effect of cognitive retraining (CR) versus mindfulness training (MT) on neuropsychological test performance in patients with early AD.

Methods And Materials: We administered CR and MT strategies in two prospectively enrolled groups of individuals (N = 34) who met the criteria for mild cognitive impairment (MCI) due to AD.

Evidences of localized coastal warming near major urban centres along the Indian coastline: past and future trends.

Large-scale urbanization near the coasts is reported to directly impact physical and biogeochemical characteristics of near shore waters, through hydro-meteorological forcing, developing abnormalities such as coastal warming. This study attempts to understand the impact-magnitude of urban expansion on coastal sea surface temperature (SST) rise in the vicinity of six major cities along the Indian coastline. Different parameters such as air temperature (AT), relative humidity (RH), wind speed (WS), precipitation (P), land surface temperature (LST) and aerosol optical depth (AOD) representing the climate over the cities were analysed and AT was found to have highest correlation with increasing coastal SST values, specifically, along the western coast (R > 0.

CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation.

In this study, we developed novel hyaluronic acid cross-linked zein nanogels (HA-Zein NGs) to deliver the potential anticancer agent curcumin (CRC), a naturally occurring phytochemical drug in cancer cells. In vitro studies showed that they are highly compatible with the tested cell lines. They showed CD44 specific uptake in CT26 cell line more than by the CD44 receptor pre-inhibited CT26 cells.

Drug- and Gene-eluting Stents for Preventing Coronary Restenosis.

Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major drawback, demanding improvement in stent technology.

Bioreducible branched poly(modified nona-arginine) cell-penetrating peptide as a novel gene delivery platform.

Cell-penetrating peptides (CPPs) have been widely used to deliver nucleic acid molecules. Generally, CPPs consisting of short amino acid sequences have a linear structure, resulting in a weak complexation and low transfection efficacy. To overcome these drawbacks, a novel type of CPP is required to enhance the delivery efficacy while maintaining its safe use at the same time.