Genotyping and phenotyping CYP3A4\CYP3A5: no association with antiplatelet effect of clopidogrel.

The objective of this study was to determine the impact of polymorphism of CYP3A subfamily isoenzymes (allelic variants of CYP3A4*22 and CYP3A5*3) on the efficacy clopidogrel in patients with an acute coronary syndrome (ACS), who have undergone percutaneous coronary intervention (PCI). Platelet activity was determined on a VerifyNow P2Y12 test system in 81 patients with ACS aged 37-91 who had PCI. The activity of CYP3A4/5 was expressed as the ratio of the concentrations of cortisol and 6β-hydroxycortisol was performed by using high performance liquid chromatography.

[Features of development, clinical picture and surgical treatment policy of destructive forms of pulmonary tuberculosis in the North].

In 135 patients, follow-up clinical, X-ray, immunological, and pathomorphological studies revealed that destructive changes in the form took place as an extensive specific process involving more than one lobe with bronchogenic dissemination and, commonly, as caseous pneumonia. Despite the extensive destructive changes, a tuberculous process is torpid, by showing mild clinical manifestations of the onset of the disease. Early lung tissue fibroplastic changes lead to an irreversible process after 4-5 months of antibiotic therapy, which suggests failure to cure them and makes it necessary to apply surgical treatments.

[Characteristics of epidemiology and clinical course of pulmonary tuberculosis in inhabitants of Northern Russia].

Pathogenetic and clinical features of the disease were studied in 126 tuberculous patients living in the North of Russia. Tuberculomas in them were found to form primarily from a caseous-pneumonic focus, clinical symptoms were manifest. Anatomically, homogeneous tuberculomas predominated in the immigrants, while a laminar type occurred more frequently in the native population (34.