Publications by authors named "K P Robledo"
Objective: We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at 2 years by 40% compared to a lifestyle program alone. To develop a personalized approach to treatment, we aimed to explore a prognostic model for incident type 2 diabetes at 2 years and investigate biomarkers predictive of the testosterone effect.
Design: Model development in 783 men with impaired glucose tolerance but not type 2 diabetes from Testosterone for Prevention of Type 2 Diabetes; a multicenter, 2-year trial of Testosterone vs placebo.
Article Synopsis
- The study investigates how the age-related microRNA miR156 influences the development of extrafloral nectaries (EFNs) in two species of passion flower.
- Results show that manipulation of miR156 affects both leaf maturation and EFN formation, with overexpression leading to smaller and fewer EFNs, while reduced activity results in larger EFNs in one species.
- This research highlights a connection between miR156 activity, nectar sugar profiles, and the ecological interactions between EFNs and ants, underscoring the role of the miR156/SPL module in regulating these traits based on leaf age.
We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review.
Arch Dis Child Fetal Neonatal Ed
December 2024
Article Synopsis
- * A systematic search yielded 62 relevant trials, revealing that 87% did not factor in multiple births for sample size calculations, and almost half ignored the clustering effect of multiple births in their analyses.
- * The findings highlight ongoing issues in trial designs that overlook the complexities of multiple births, signaling a need for trialists to better incorporate these considerations and for readers to critically assess the methodologies in neonatal research.
Background: Protein biomarkers that reflect different pathophysiological pathways have been associated with the risk of adverse cardiovascular events. However, it is uncertain whether these associations are sustained with increasing years after the biomarkers are measured.
Methods And Results: In this cohort study, 7745 patients with coronary heart disease who participated in the LIPID (Long-Term Intervention With Pravastatin in Ischemic Disease) trial, BNP (B-type natriuretic peptide), troponin I, cystatin-C, C-reactive protein, d-dimer and midregional proadrenomedullin were measured at baseline and after 1 year.
Background: Previous studies have shown that major surgical and medical hospital admissions are associated with cognitive decline in older people (aged 40-69 years at recruitment), which is concerning for patients and caregivers. We aimed to validate these findings in a large cohort and investigate associations with neurodegeneration using MRI.
Methods: For this population-based study, we analysed data from the UK Biobank collected from March 13, 2006, to July 16, 2023, linked to the National Health Service Hospital Episode Statistics database, excluding participants with dementia diagnoses.