Publications by authors named "K P Paily"

Outbreaks of acute encephalitis syndrome (AES) with high fatality and disability, are reported every year in the Gorakhpur region of Uttar Pradesh, India, with the etiology of >60% of the cases being attributed to scrub typhus. In the present study, the prevalence of Orientia tsutsugamushi, the etiological agent of scrub typhus, was investigated among animal hosts and their ectoparasitic trombiculid mites prevalent in AES-reported areas of Gorakhpur. A total of 154 rodents/shrews were collected using 777 Sherman traps set in 12 study villages, and the overall trap rate was 19.

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Article Synopsis
  • Scrub typhus cases are frequently reported in Puducherry and surrounding areas, but there's limited knowledge about the presence of its causative agent, Orientia tsutsugamushi, and its vectors.
  • The study involved collecting and identifying trombiculid mites from rodents and shrews, using tests and DNA extraction to detect the pathogen.
  • Results showed a significant presence of the known vector, Leptotrombidium deliense, and a high rate of antibodies against O. tsutsugamushi in the sampled animals, indicating a high risk of scrub typhus transmission in the villages studied.
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The peripheral blood samples from domestic dogs (n=47) and wild rats (n=25) in the Kani Tribe settlements, located southernmost part of the Western Ghats, Thiruvananthapuram district, Kerala, India were examined for Leishmania infection. This area is known for cases of leishmaniasis with cutaneous manifestations and sandfly abundance. The tribes domesticate dogs to protect them from untoward activities of wild animals.

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Two of the potential bacterial isolates, viz., Pseudomonas fluorescens (VCRC B-426) and Bacillus subtilis (VCRC B-471) whose toxins kill the mosquito pupae/larvae have been identified at our center. As the mode of action of these bacteria are not known, an attempt was made to find out the binding sites of the toxic proteins through immunological methods.

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In rubber plantations, tree holes are one of the major types of breeding habitats of Aedes mosquitoes which transmit dengue and chikungunya. A mermithid nematode, Romanomermis iyengari, was evaluated in tree holes for its efficacy in controlling Aedes albopictus. Infection of mosquito larvae by the nematode was determined through microscopic examination on the next day of application, and evaluation of immature density of mosquito was done on the seventh day.

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