Orange-Red-Emitting Carbon Dots for Bilirubin Detection and Its Antibacterial Activity Against and .

In this study, orange-red-emitting carbon dots (OR-CDs) were prepared from -phenylenediamine (-PDA) and urea as starting precursors through the hydrothermal method. The OR-CDs exhibited bright orange-red fluorescence at 618 nm when excited at 480 nm. The obtained OR-CDs exhibited stable photophysical properties under different physiological conditions.

Automatic multi-structure pediatric knee bone segmentation using optimal multi-level Otsu thresholding to tackle intensity homogeneity in bone structures.

Recent studies in medical image segmentation involve new automatic approaches where active learning models are useful with less training samples. Presence of homogenous and heterogenous intensities for a single anatomical structure in pediatric musculoskeletal MR images affects the accuracy in terms of segmentation and classification of labels. This study addresses the homogeneity in intensity issues and introduces a new pre-training pipeline framework of Multi-level Otsu thresholding image as separate channel for 3D UNet model training.

A safety-catch protecting group strategy compatible with Boc-chemistry for the synthesis of peptide nucleic acids (PNAs).

Peptide Nucleic Acids (PNAs) are an intriguing class of synthetic biomolecules with great potential in medicine. Although PNAs could be considered analogs of oligonucleotides, their synthesis is more like that of peptides. In both cases, a Solid-Phase Synthesis (SPS) approach is used.

An Optimal Stacked ResNet-BiLSTM-Based Accurate Detection and Classification of Genetic Disorders.

Gene is located inside the nuclease and the genetic data is contained in deoxyribonucleic acid (DNA). A person's gene count ranges from 20,000 to 30,000. Even a minor alteration to the DNA sequence can be harmful if it affects the cell's fundamental functions.

Methionine-Containing Peptides: Avoiding Secondary Reactions in the Final Global Deprotection.

The solid-phase synthesis of Met-containing peptides using a fluorenylmethoxycarbonyl (Fmoc)/-butyl (Bu) protection scheme is inevitably accompanied by two stubborn side reactions, namely, oxidation and -alkylation (-butylation), which result in the formation of Met(O) and sulfonium salt impurities of the target peptide, respectively. These two reactions are acid-catalyzed, and they occur during the final trifluoroacetic (TFA)-based acidolytic cleavage step. Herein, we developed two new cleavage solutions that eradicate the oxidation and reduce -alkylation.