The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity.

The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is largely unexplored. In this study, we characterize tPA expression, activity, and localization in the SN using a combination of retrograde tracing and β-galactosidase tPA reporter mice.

The Impact of Role Models on Sexual Minority Women: A Qualitative Interview Study.

Sexual minority women (e.g., lesbian, bisexual, pansexual) have increased risk of experiencing various mental health problems compared to sexual minority men and heterosexual individuals.

[Endocrinology, diabetology and metabolism in the 150 years of the DMW - A long and sustainable relationship].

The DMW is celebrating its 150th anniversary - and this period is precisely when endocrinology and diabetology evolved from the first experiments to molecular biology, genetic, and bioinformatics research. The DMW has always accompanied this process with numerous important publications, some of which are highlighted in this article.

Mechanisms of Metal-Induced Hepatic Inflammation.

Purpose Of Review: Worldwide, there is an increasing prevalence of hepatic diseases. The most common diseases include alcoholic-associated liver disease (ALD), metabolic dysfunction-associated fatty liver disease/ metabolic dysfunction-associated steatohepatitis (MAFLD/MASH) and viral hepatitis. While there are many important mediators of these diseases, there is increasing recognition of the importance of the inflammatory immune response in hepatic disease pathogenesis.