Publications by authors named "K P Maguire"
Lifetime exposures to potentially psychologically traumatic events (PPTEs) among Royal Canadian Mounted Police (RCMP) cadets starting the Cadet Training Program (CTP) appear lower than exposures reported by serving RCMP, but the prevalence of PPTE exposures during the CTP remains unknown. The current study assessed PPTE exposures during the CTP and examined associations with mental disorders among RCMP cadets. Participants were cadets (n = 449, 24.
View Article and Find Full Text PDFIntroduction: Amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease (AD). The accumulation of beta-amyloid protein is believed to be a crucial step in the development of AD. Therefore, understanding the complex biology of APP and its various cleavage products may be useful for developing effective therapeutic strategies for AD.
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- Protein-protein interactions (PPIs) are essential for biological functions and play a key role in diseases like cancer and neurological disorders by altering PPI networks.
- Understanding the kinome, a group of 518 human kinases, is crucial as they are often dysregulated in diseases and can be targeted with drugs that inhibit their activity.
- The newly developed 2nd generation kinobead competition and correlation analysis (2 gen kiCCA) method allows for better identification and mapping of kinase PPIs, leading to insights into signaling pathways and therapeutic targets in diseases like neuroblastoma.
Background: Patellofemoral osteochondral fractures (OCFs) have the potential to hinder patients' function and quality of life. Several fragment fixation techniques have been described, with both metallic screw and bioabsorbable fixation showing favorable functional outcomes. Despite the promising results associated with both fixation methods, no study has directly compared their functional outcomes.
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