Publications by authors named "K P Ishitani"
Effect of dupilumab on otitis media associated with eosinophilic chronic rhinosinusitis.
Braz J Otorhinolaryngol
January 2025
Objective: Eosinophilic Otitis Media (EOM) is an intractable disease caused by type 2 inflammation, such as Eosinophilic Chronic Rhinosinusitis (ECRS) and bronchial asthma. Biologics have recently been used to treat ECRS and bronchial asthma. Biologics are not indicated for EOM; however, because approximately 10% of ECRS cases has concomitant EOM, concomitant EOM improvement has been observed when dupilumab is administered for ECRS.
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- Orbital apex syndrome (OAS) causes visual loss, double vision, and eye pain due to various underlying conditions, including acute invasive fungal rhinosinusitis (AIFRS).
- A case study presented a 76-year-old man with OAS linked to AIFRS, who underwent surgery and received antifungal treatment after a failed corticosteroid regimen.
- The findings highlight the difficulty in differentiating between AIFRS-induced OAS and other forms, emphasizing the importance of conducting a biopsy before corticosteroid treatment to avoid worsening fungal infections and ensure better patient outcomes.
Article Synopsis
- Ethmoidal arteries are vulnerable to injury during endoscopic sinus surgery, prompting this study to investigate their locations in Japanese patients.
- A review of CT images from 50 patients showed that anterior ethmoidal arteries (AEAs) and posterior ethmoidal arteries (PEAs) were consistently present, with a notable percentage running below the anterior skull base (ASB).
- The findings suggest that surgeons should exercise caution when operating near AEAs, especially in patients with supraorbital ethmoid cells, to minimize the risk of injury.
Objective: This study compares baseline clinical characteristics, physical function testing, and patient-reported outcomes for patients undergoing primary cytoreductive surgery versus neoadjuvant chemotherapy, with the goal of better understanding unique patient needs at diagnosis.
Methods: Patients with suspected advanced stage (IIIC/IV) epithelial ovarian cancer undergoing either primary cytoreductive surgery or neoadjuvant chemotherapy were enrolled in a single-institution, non-randomized prospective behavioral intervention trial of prehabilitation. Baseline clinical characteristics were abstracted.
Opioids are almost mandatorily used for analgesia for cancer pain and postoperative pain. Opioid analgesics commonly induce nausea as a side effect. However, the genetic factors involved are still mostly unknown.
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