Association of Mucin-Degrading Gut Microbiota and Dietary Patterns with Colonic Transit Time in Constipation: A Secondary Analysis of a Randomized Clinical Trial.

Background: The relationship between gut microbiota composition, lifestyles, and colonic transit time (CTT) remains poorly understood. This study investigated associations among gut microbiota profiles, diet, lifestyles, and CTT in individuals with subjective constipation.

Methods: We conducted a secondary analysis of data from our randomized clinical trial, examining gut microbiota composition, CTT, and dietary intake in baseline and final assessments of 94 participants with subjective constipation.

Mobile health applications for older people in Asia: protocol for a systematic review of end-user perceptions and recommendations.

Introduction: Mobile technology has revolutionised the way people interact with others and gain access to healthcare services. Given that cultural background is a strong moderator for technology penetration, this systematic review aims to examine end-user perceptions and design recommendations for mobile health applications among Asian older people.

Methods And Analysis: Five electronic databases (PubMed, CINAHL, PsycINFO, Medline and Cochrane Central Register of Controlled Trials) will be searched until May 2025.

Thoracic vertebral body erosion due to a perianeurysmal outpouching lesion after thoracic endovascular aortic repair: a case report and literature review.

Background: The safety of endovascular treatment, such as thoracic endovascular aortic repair (TEVAR), for a descending thoracic aortic aneurysm has been well-established, with a reported low postoperative mortality rate but higher incidences of long-term complications such as endo-leakage, device failure, and aneurysm-related death. Based on this, we report the first case of massive thoracic vertebral body erosion due to a perianeurysmal outpouching lesion after TEVAR.

Case Presentation: A 77-year-old female with a history of TEVAR due to descending thoracic aortic arch aneurysm 4 years ago was referred from the cardiovascular clinic to the spine center.

Genomic Insights into from Southern Korea: Pathogenicity, Antimicrobial Resistance, and Phylogenetic Distinctions.

, a significant cause of gastroenteritis and a growing public health concern, has become increasingly prevalent owing to the rise in ocean temperatures driven by climate change. This study aimed to characterize the genetic diversity, pathogenic potential, and antimicrobial resistance (AMR) profiles of strains isolated from the southern coastal region of Korea. Using whole genome sequencing (WGS) and advanced bioinformatics tools, we identified novel sequence types through multilocus sequence typing and serotyped isolates using the VPsero database.

Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6.

Human Interleukin-6 (hIL-6) is a pro inflammatory cytokine that binds to its receptor, IL-6Rα followed by binding to gp130 and subsequent dimerization to form a hexamer signaling complex. A critical inflammation mediator, hIL-6 is associated with a diverse range of diseases and monoclonal antibodies are in clinical use that either target IL-6Rα or hIL-6 to inhibit signaling. Here, we perform high throughput structure-based computational screening using ensemble docking for small molecule antagonists for which the target conformations were taken from 600 ns long molecular dynamics simulations of the apo protein.