Publications by authors named "K P H Pritzker"
Objective: Needle biopsy is a common technique used to obtain cell and tissue samples for diagnostics. Currently, two biopsy methods are widely used: (i) fine-needle aspiration biopsy (FNAB) and (ii) core needle biopsy (CNB). However, these methods have limitations.
View Article and Find Full Text PDFIntroduction: Ureteral stents facilitate recovery and avoid external drains in pediatric ureteral reconstruction. Extraction strings avoid the need for a secondary cystoscopy and anesthetic. Due to concerns regarding febrile UTIs in children with extraction strings, we retrospectively assessed the relative risk of UTI in children with extraction strings.
View Article and Find Full Text PDFAssessing Oral Epithelial Dysplasia Risk for Transformation to Cancer: Comparison Between Histologic Grading Systems Versus S100A7 Immunohistochemical Signature-based Grading.
Appl Immunohistochem Mol Morphol
July 2023
Article Synopsis
- The 3-tier dysplasia grading system has been traditionally used for assessing oral epithelial dysplasia but is considered inadequate for predicting cancer risk.
- A study compared this 3-tier system, a proposed 2-tier system, and an S100A7 biomarker-based grading system using biopsy samples from 48 patients.
- Results showed that while both dysplasia systems had low predictor value for cancer transformation, the S100A7 system demonstrated high agreement among observers and effectively indicated cancer risk, underscoring the need for more reliable assessment tools.
Introduction: Diseases related to chronic persisting inflammation are amongst the largest sources of morbidity and health costs, yet biomarkers for early diagnosis, prognosis, and treatment response are not sufficiently effective.
Areas Covered: This narrative review discusses how inflammation concepts have evolved from ancient times to the present, and places in perspective the use of blood-based biomarkers to assess chronic inflammatory diseases. From reviews of biomarkers in specific diseases, emerging biomarker classifiers and their clinical utility is discussed.
Non-invasive therapeutic ultrasound (US) methods, such as high-intensity focused ultrasound (HIFU), have limited access to tissue targets shadowed by bones or presence of gas. This study demonstrates that an ultrasonically actuated medical needle can be used to translate nanoparticles and fluids under the action of nonlinear phenomena, potentially overcoming some limitations of HIFU. A simulation study was first conducted to study the delivery of a tracer with an ultrasonically actuated needle (33 kHz) inside a porous medium acting as a model for soft tissue.
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