Publications by authors named "K P Govindan"

We have developed a novel ultrasound technique that generates significant amounts of CF-substituted benzo[4,5] imidazo [1,2-]pyrimidine analogues from easily accessible starting materials in an ecologically friendly and efficient approach. This method is notably helpful for producing physiologically relevant compounds containing the imidazopyrimidine unit, which serves as a versatile building block for the synthesis of -fused heterocycles and is devoid of metals, solvents, additives, and catalysts. Additionally, utilizing ultrasound in an open-air environment, a range of polyfluoro-ynones were successfully reacted with 2-aminobenzimidazole, generating a diverse array of polyfluoroimidazo[1,2-]pyrimidine derivatives.

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We present a novel, eco-friendly and one-pot approach for synthesizing unsymmetrical oxalamides with the aid of dichloroacetamide and amine/amides in the presence of CBr in a basic medium. The use of water as a potent supplement for the oxygen atom source and the detailed mechanism have been disclosed. Moreover, the protocol involves triple cleavage of CClBr and the formation of new C-O/C-N bonds, with the advantage of achieving selective bromination using CBr with good to excellent yield under mild conditions.

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The present study is an attempt to investigate the potentiality of Rhizoclonium hieroglyphicum in the removal of reactive red 239 (RR239) from aqueous solution and to assess the toxicity of the treated dye solution. Optimisation of the process variables namely dye and biosorbent concentrations, pH, temperature and incubation time for RR239 removal was performed using Response Surface Methodology (RSM) assisted Box Behnken Design (BBD) model. The recycling and regeneration efficiency of the dye adsorbed alga was evaluated using different eluents under optimized conditions.

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Introduction: Prolonged COVID-19 pandemic accelerates the emergence and transmissibility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants through the accumulation of adaptive mutations. Particularly, adaptive mutations in spike (S) protein of SARS-CoV-2 leads to increased viral infectivity, severe morbidity and mortality, and immune evasion. This study focuses on the phylodynamic distribution of SARS-CoV-2 variants during the year 2021 in India besides analyzing the functional significance of mutations in S-protein of SARS-CoV-2 variants.

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FeCl-catalyzed decyanation of α-aminonitriles followed by a [4 + 2] annulation with terminal alkynes has been developed to synthesize 2,4-diaryl quinolines. A broad range of aniline, aldehyde, and arylacetylene derivatives were well tolerated to access 2,4-diaryl quinolines in moderate to good yields. The control experiment studies suggested that the reaction proceeds through a nonradical pathway involving Povarov-type [4 + 2] annulation from the generated iminium species.

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