Growth and dormancy control of myeloma cells by mesenchymal stem cells.

Bone marrow mesenchymal stem cells (MSCs) may have contrasting impacts on the progression of multiple myeloma (MM). Priming normal MSCs, by culturing them with MM cells, mimics the MSC-induced MM growth. We studied the contrasting effects of conditioned medium (CM) from unprimed or primed MSCs on growth of MM cells from newly diagnosed cases.

Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase.

Purpose: Diabetes mellitus, one of the major causes of erectile dysfunction, leads to a poor response to phosphodiesterase-5 inhibitors. Heat shock protein 70 (Hsp70), a ubiquitous molecular chaperone, is known to play a role in cell survival and neuroprotection. Here, we aimed to assess whether and how Hsp70 improves erectile function in diabetic mice.

Mixed NHC-thiolato complexes of palladium: understanding the formation of di- mononuclear complexes.

The preference for the formation of mono- dinuclear mixed carbene/thiolato complexes of Pd has been studied with three types of N-heterocyclic carbenes derived from benzimidazole, imidazole and 1,2,4-triazole. The complexes were prepared by treatment of halido/NHC precursors with sodium isopropylthiolate in a salt metathesis reaction. Mononuclear complexes are formed when the sulfur and carbon donors are exclusively to each other, while their arrangement preferably leads to dinuclear complexes with μ-bridging thiolato ligands.

The Magneto Electron Statistics in Heavily Doped Type-Intrinsic- Type-Intrinsic Structures.

In this paper we study the Electron Statistics in Heavily Doped Type-Intrinsic- Type-Intrinsic structures of non-linear optical, tetragonal and opto-electronic materials in the presence of magnetic quantization. It is found taking such heavily doped structures of Cd₃As₂, CdGeAs₂, InAs, InSb, HgCdTe, InGaAsP as examples that the Fermi energy (E) oscillates with inverse quantizing magnetic field (1/) and increases with increasing electron concentration with different numerical magnitudes which is the signature of respective band structure. The numerical value of the Fermi energy is different in different cases due to the different values of the energy band constants.

Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice.

Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower cavernous VASH1 expression than in the potent man.